IVF Treatment in Women With Immature Oocytes in Previous Cycle
Status:
Unknown status
Trial end date:
2020-06-01
Target enrollment:
Participant gender:
Summary
In standard IVF stimulation cycle,human chorionic gonadotropin (hCG) is usually used at the
end of controlled ovarian hyperstimulation (COH) as a surrogate to only the luteinizing
hormone (LH) surge. Yet, the last dose of follicle stimulating hormone (FSH) is usually given
between 12-24 hours before the hCG triggering dose.One protocol used at the investigators
unit, after a cycle with low proportion of mature oocytes per number oocytes retrieved, is
triggering with high dose hCG (500 mcg)-38 hours prior to oocyte aspiration.
Lately, new researches showed that dual triggering of final oocyte maturation with a
combination of GnRH- agonist and hCG, could improve the live-birth rate of normal responders
undergoing the GnRH-antagonist COH protocol
Another treatment option is high dose hCG. Only few case reports have described the use of
high dose hCG after aspiration of non mature oocytes at a previous cycle. At the
investigators IVF unit, patients with previous history of high percentage of immature oocytes
retrieved, are triggered at the following cycle, either with double trigger or with high dose
of hCG decided by the physician consulting the patient. It is still not known with which way
of triggering more mature oocytes is retrieved.
The aim of this study is to perform a prospective randomized controlled study in patients
with low proportion of mature-MII oocytes oocytes (<75%) per number oocytes retrieved,
despite normal response to controlled ovarian hyperstimulation ( COH ) comparing cycles
triggered with high dose hCG to those triggered with hCG+GnRH agonist.