IV vs Oral Acetaminophen in Spine Fusion Perioperative Care
Status:
Enrolling by invitation
Trial end date:
2021-10-01
Target enrollment:
Participant gender:
Summary
The United States is currently experiencing an explosive opioid epidemic. In 2014 alone,
28,647 Americans died from an opioid associated overdose; the annual death toll has increased
by over 300% since 2000. The epidemic poses a complex scenario for physicians administering
treatment for postoperative pain, as opioids are key analgesic agents in treating moderate to
severe pain. In order to reduce the patients risk for long term opioid use and the associated
side effects, physicians have begun shifting to multimodal analgesic approaches to treat
postoperative pain. These approaches have been found to be similarly efficacious, while also
reducing opioid usage and associated side effects, such as: nausea, vomiting, and ileus.
This study proposes a multimodal analgesic approach, which the investigators believe will
reduce short and long term opioid usage, the associated side effects, and the financial
burden. Intravenous acetaminophen is an effective medication for both primary and adjunctive
pain management, however its use is limited by a high cost to perceived benefit ratio. Oral
acetaminophen is a relatively inexpensive option, although perhaps less effective than the IV
option, and also often not feasible to utilize in the immediate post-operative period when
patients are unable to safely swallow pills. The hypothesis of this investigation is to
understand if adding intravenous acetaminophen to the perioperative care regimen after lumbar
spinal surgery will result in improved pain management in the perioperative period while
decreasing opioid usage and related complications.
Phase:
Phase 4
Details
Lead Sponsor:
Hospital for Special Surgery, New York
Collaborator:
Mallinckrodt
Treatments:
Acetaminophen Acetaminophen, hydrocodone drug combination