This study addresses the focus areas of Post-Operative Pain Management. We propose a
randomized, triple-blind, placebo-controlled trial to investigate the efficacy of a systemic
infusion of intravenous lidocaine as a non-opioid method of post-operative pain management
following postoperative spinal fusion for adolescent idiopathic scoliosis (AIS). The outcomes
assessed will be (1) the effect of intravenous lidocaine on post-operative opioid
consumption, both in-hospital and at three-month follow-up, (2) the effect of intravenous
lidocaine on the immunophenotype expressed following surgery, and (3) the effect of
intravenous lidocaine on recovery from surgery as assessed by the Patient Reported Outcomes
Measurement Information System-Computer Adaptive Tests for Pain Interference (PI) and
Mobility (M) (PROMIS-CAT). Thus, we propose a study of a non-opioid method of pain control to
minimize opioid consumption in-hospital and at three-months postoperatively, with primary
outcomes measures that include morphine-equivalent opioid consumption and PROMIS-Mobility to
assess recovery. In addition, we will test the ability of systemic lidocaine to attenuate the
systemic inflammatory response to major spine surgery. The immunologic response to surgery
has been associated with rehabilitation and recovery following total hip arthroplasty and
this study will provide data to support further work.