Overview

IV Acetaminophen for Postoperative Pain Analgesia After Laparoscopic Hysterectomy

Status:
Completed
Trial end date:
2016-09-01
Target enrollment:
0
Participant gender:
Female
Summary
The objective of this study is to quantify the change in post-operative pain scores and narcotic requirements in women receiving pre and post-operative IV acetaminophen compared to placebo in women undergoing laparoscopic hysterectomy.
Phase:
Phase 4
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
University of Pittsburgh
Treatments:
Acetaminophen
Criteria
Inclusion Criteria:

- Women aged 18-75

- Ability to read and write in English (our post-operative pain log is only available in
English)

- Planning a laparoscopic hysterectomy (includes total laparoscopic hysterectomy,
laparoscopic supracervical hysterectomy, laparoscopically assisted vaginal
hysterectomy, with or without salpingooophorectomy)

Exclusion Criteria:

- Answering yes to any of the following questions: "Do you have a history of liver
disease, kidney disease, hepatitis C, history of liver failure, greater than 3 drinks
per day or being have you ever been told by your doctor that they should not take
acetaminophen"

- History of cardiac arrhythmia

- History of jaundice

- Acute abdominal inflammatory or infectious process at time of surgery

- Known malignancy at time of surgery

- Known pregnancy at time of surgery

- Plan to perform additional significant surgical procedure at the time of hysterectomy
such as extensive excision of endometriosis on bowel or bladder or pelvic
reconstructive procedure

- >6cm abdominal incision in order to remove the uterus at time of study-related
hysterectomy

- Regular use of narcotic pain medication (defined as use on most days of the week at
any point in the past 3 months)

- Allergy to acetaminophen

- Women who weigh less than 50 kilograms on the day of surgery.