IV Acetaminophen for Acute Post Operative Pain in C-Section Patients

• Status: Completed
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

Post-operative pain management after C-section is an important topic as the number of elective c-sections increases each year. Pain is managed either by giving opioids or by using non-opioids. The purpose of this study is to evaluate the effectiveness of IV Acetaminophen in pain relief and its impact in the usage of post-operative opioid requirements and opioid associated complications. The hypothesis is that four doses of IV Acetaminophen in conjunction with intrathecal or epidural morphine given to the patients after c-section will reduce post-operative opioid requirements and opioid associated complications.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Montefiore Medical Center
• Treatments: Acetaminophen

Criteria

Inclusion Criteria:

• Elective full term CS patients

• Age 18 and above

• ASA I-III

Exclusion Criteria:

• Allergic reaction to IV acetaminophen

• Not able to understand and sign the research consent

• Pregnancy induced hypertension or pre-eclampsia patients

• Planned intensive care admission patients

• Patients with severe hepatic impairment or active liver diseases (Two fold increase in any of the liver enzymes)

• Patients with serum creatinine>2mg/dl

• For nursing mothers, any evidence of hepatic dysfunction of the new born