IV Acetaminophen and Patent Ductus Arteriosus

• Status: Completed
• Trial end date: 2019-06-30
• Target enrollment: 0
• Participant gender: All

Summary

This is a randomized controlled trial to evaluate the efficacy of IV acetaminophen versus IV ibuprofen in closing a hemodynamically significant patent ductus arteriosus in preterm infants.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Albany Medical College
• Treatments: Acetaminophen; Ibuprofen

Criteria

Inclusion Criteria:

• preterm infants 23-30 weeks gestation,

• PDA requiring treatment

Exclusion Criteria:

• infection,

• congenital heart disease,

• genetic syndrome,

• NEC,

• pulmonary hypertension,

• hydrops,

• intestinal perforation,

• grade 3 or 4 IVH,

• serum creatinine >1.5,

• previous treatment with a COX inhibitor.