ITT4 Intratesticular Hormonal Milieu in Man (ITT4)
Status:
Completed
Trial end date:
2012-03-01
Target enrollment:
Participant gender:
Summary
The purpose of this research study is to determine how much male hormone, testosterone, is
necessary to maintain sperm production in the testis. This knowledge will be used to help in
the development of a safe male hormonal contraception.
Specific Aims:
1. to determine if ketoconazole plus acyline will suppress intratesticular
testosterone(ITT) to a greater degree than acyline alone.
2. to determine if dutasteride plus acyline will suppress intratesticular
dihydrotestosterone (IT-DHT) to a greater degree than acyline alone.
3. to determine if anastrazole plus acyline will suppress intratesticular estradiol(IT-E2)
to a greater degree than acyline alone.
Phase:
Phase 1/Phase 2
Details
Lead Sponsor:
University of Washington
Collaborator:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)