Lassa fever (LF) is a viral haemorrhagic fever responsible of 5000 deaths per year in West Africa, with in-hospital mortality at 12%. Transmission to humans occurs mainly via direct or indirect exposure to excreta from the rodent reservoir, mainly made up of Mastomys natalensis . Less frequently, LASV may also be transmitted from human to human and cause nosocomial outbreaks. Ribavirin is the only treatment available with worrying toxicity, questionable efficacy and low access because of its high cost. Consequently, there is an urgent need for new drugs to treat LF patients. The Research and Development (R\&D) Blueprint of the World Health Organization (WHO) has included LF in the list of priority diseases for urgent research and development.
The INTEGRATE consortium is an unprecedented international collaboration on Lassa fever of 15 partners from 10 countries across West Africa, Europe and North America and across several disciplines (epidemiological researchers, social scientists, medical health facility professionals, humanitarian actors, etc.).
Phase:
PHASE2
Details
Lead Sponsor:
Irrua Specialist Teaching Hospital
Collaborators:
Alex Ekwueme Federal University Teaching Hospital Alliance for International Medical Action ANRS, Emerging Infectious Diseases Bernhard Nocht Institute for Tropical Medicine Centre de Recherche Médicale de Lambaréné Donka Hospital, Conakry Federal Medical Centre, Owo Fondation pour la Recherche Scientifique, Benin Médecins Sans Frontières, Belgium Phebe Hospital, Liberia Programme PAC-CI, Site ANRS-MIE de Côte d'Ivoire University of Bordeaux University of Hamburg-Eppendorf University of North Carolina
Treatments:
Dexamethasone favipiravir Ribavirin Standard of Care