IO vs IV Vancomycin in Tourniquetless TKA

• Status: Recruiting
• Trial end date: 2024-01-25
• Target enrollment: 0
• Participant gender: All

Summary

Purpose of this study is to compare the efficacy of intravenous and intraosseous antibiotic administration techniques during tourniquetless total knee arthroplasty.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The Methodist Hospital Research Institute
• Treatments: Vancomycin

Criteria

Inclusion Criteria:

• Patient is undergoing a primary total knee arthroplasty.

• Patient is able to understand the study design and intervention and gives informed consent to participate in the study. No LAR consents will be utilized for this study.

• Age >18 years.

• Total knee arthroplasty performed without the use of a tourniquet.

Exclusion Criteria:

• Previous surgery on the knee (including arthroscopic knee surgery)

• BMI above 35

• Contraindication to receiving vancomycin, cefepime, ancef, or other standard of care pre-operative antibiotic (allergy, medical issue, etc).

• Inability to locate the tibial tubercle or administer the IO infusion

• Refusal to participate

• Uncontrolled Diabetes Mellitus type 1 or 2, defined as Hemoglobin A1C >7.5.

• Immunocompromised or immunosuppressed patients (HIV, Hep C, End-Stage Renal Disease, dialysis, transplant, chemo/radiation treatment in last 6 months, and immunosuppresive medications)