Overview

INtravesical Antimicrobial Agents v STANDard Oral Antibiotics for the Treatment of Acute UTI in Women With rUTI

Status:
Withdrawn
Trial end date:
2018-07-05
Target enrollment:
0
Participant gender:
Female
Summary
Women have problems with oral antibiotics, including vagina and bowel infections. Also, bacteria causing urinary infections are becoming more resistant to oral antibiotis. Placement of antibiotic directly into the bladder does not cause these problems and are at doses that are may be able to stop bacteria from being resistant to antibiotics.
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Mayo Clinic
Treatments:
Anti-Bacterial Agents
Anti-Infective Agents
Gentamicins
Nitrofurantoin
Criteria
Inclusion Criteria:

- Ability to understand study procedures and to comply with them for the entire length
of the study.

Exclusion Criteria:

- Patients who report that they are pregnant.

- Patients with a positive urine pregnancy test

- Patients with a history of renal transplantation.

- Patients with bladder augmentation procedures using bowel.

- Patients with poorly controlled Type II diabetes, Hgb A1C >6.5%

- Patients with spinal cord injury, ASIA Impairment Scale of C or higher.

- Patients with pelvic surgery within 6 months.

- Patients with urologic procedure within 6 months.

- Patients with a history of reconstructive urologic surgery, such as reflux, congenital
abnormality.

- Immunocompromised patients being treated for malignancy or a history of actively
treated malignancy within 5 years.

- Patients with active systemic autoimmune disease.

- Patients on systemic immunosuppression.

- Use of antibiotic prophylaxis within 6 months

- Use of antibiotics within 10 days of active infection

- Allergy/sensitivity to gentamicin or nitrofurantoin.

- Current drug or alcohol use or dependence that, in the opinion of the site
investigator, would interfere with adherence to study requirements.

- Inability or unwillingness of individual to give written informed consent.