INTEnsity of ovariaN Stimulation and Embryo Quality
Status:
Not yet recruiting
Trial end date:
2024-06-01
Target enrollment:
Participant gender:
Summary
The management of suboptimal ovarian responders remains a challenging task in IVF. These
patients are frequently managed with an intense stimulation protocol of ovarian stimulation
in order obtain the maximum number of embryos and, therefore, maximize the cumulative live
birth rate. However, the concept of "the more the better" has been recently defied by the one
of "mild stimulation". Defenders of this protocol state that with mild stimulation only the
best quality oocytes are allowed to grow and, therefore, higher quality embryos will be
obtained. However, the impact of the intensity of ovarian stimulation on embryo quality is
far from consensual. Moreover, its effect on early embryo development has never been
evaluated.
Therefore, the investigators set out to perform this randomized controlled trial comparing
the number of GQB and the morphokinetic parameters of early embryo development in infertile
patients undergoing two different intensities of ovarian stimulation, a milder approach (CC
plus 150 IU daily dose of rFSH) and a more intense approach (300 IU daily dose of rFSH).