Vago-sympathetic activity, arterial stiffness and endothelial function are integrators of
cardiovascular risk. The aim of this pilot study is, in type 2 diabetic patients now
requiring insulin, to compare the effects of improving glycemic control on these parameters
with 3 different insulin regimens which will act especially at fasting or in post-prandial
periods or both. Non invasive explorations will be performed before randomization and after 4
to 5 weeks of insulin therapy, at fasting and each hour after a standardized breakfast.