This single center, randomized control, double blind trial will prospectively examine the
feasibility of intranasal, sub-dissociative (IN) ketamine versus intranasal fentanyl for pain
control in the pediatric emergency department setting. The investigators hypothesize that IN
ketamine may provide a safe and effective alternative to IN fentanyl for children with
suspected, isolated extremity fractures.
Eighty children ages 3-17 years with a suspected, isolated extremity fracture that requires
analgesia will be randomized to receive IN ketamine or IN fentanyl upon presentation to the
emergency department and will be followed for 2 hours for efficacy and 6 hours for safety.
Phase:
Phase 2
Details
Lead Sponsor:
Atrium Health Carolinas Healthcare System
Collaborators:
Carolinas Trauma Network Research Group Charlotte, Houston, Milwaukee Prehospital Emergency Research Nodal Center-CHaMP-ERNC