IL-6 Regulation of Energy Stores During Recovery From an Acute Exercise Bout
Status:
Recruiting
Trial end date:
2022-09-01
Target enrollment:
Participant gender:
Summary
The aim of the study is to investigate the role of exercise-induced IL-6 in regulating energy
stores and energy metabolism during recovery after an acute exercise bout. To achieve this,
30 men will be randomized to infusion placebo or tocilizumab (IL-6 receptor antibody)
combined with a 2-hour exercise bout. Stable isotope tracers will be infused to determine
substrate kinetics. Indirect calorimetry will be applied to determine substrate oxidation,
and muscle biopsies will be taken to determine substrate uptake and storage.