IL-1RA Treatment in Patients With Acute ACL Tear and Painful Effusions
Status:
Terminated
Trial end date:
2020-10-16
Target enrollment:
Participant gender:
Summary
Injury to the knee during sports participation often involves partial or full detachment of
the anterior cruciate ligament (abbreviated as ACL). ACL tears cause pain, swelling and
inflammation. While the swelling and inflammation usually goes away in time, individuals with
ACL injuries may experience pain and notice knee instability (knee slipping, etc.). Often
surgery can repair or replace the ACL within the joint, allowing individuals the ability to
walk or run again pain free or participate in sports. Unfortunately, osteoarthritis of the
knee, which also causes pain and swelling, can occur in that same knee 10-20 years later for
reasons which are not well understood.
In this research study, the investigator hopes to reduce the initial pre-operative pain. The
reduction of pain will allow for earlier movement of the knee joint and preparation for
surgery. The investigator is interested to see if the use of Kineret does decrease the risk
of developing arthritis in individuals with ACL injuries by treating them within 28 days
after their injury.