IGF-I Stimulation of Collagen Synthesis in Ehlers-Danlos Patients

• Status: Completed
• Trial end date: 2012-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The investigators want to inject insulin-like growth factor-I (IGF-I) into the patella tendon of Ehlers-Danlos patients and healthy controls to evaluate the response in collagen synthesis. Furthermore collagen synthesis is measured in muscle connective tissue and in skin.

The hypothesis is that the connective tissue in Ehlers-Danlos patients is more compliant and poorer in collagen than healthy controls, but that collagen synthesis can be stimulated by IGF-I.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Bispebjerg Hospital
• Treatments: Mecasermin

Criteria

Inclusion Criteria:

• Classic form of Ehlers-Danlos syndrome OR healthy matched control

Exclusion Criteria:

• Malignity, cardiac diseases, diabetes, tendinopathy in patella tendons