IGF-I Stimulation of Collagen Synthesis in Ehlers-Danlos Patients
Status:
Completed
Trial end date:
2012-11-01
Target enrollment:
Participant gender:
Summary
The investigators want to inject insulin-like growth factor-I (IGF-I) into the patella tendon
of Ehlers-Danlos patients and healthy controls to evaluate the response in collagen
synthesis. Furthermore collagen synthesis is measured in muscle connective tissue and in
skin.
The hypothesis is that the connective tissue in Ehlers-Danlos patients is more compliant and
poorer in collagen than healthy controls, but that collagen synthesis can be stimulated by
IGF-I.