IGF-1 and Bone Loss in Women With Anorexia Nervosa
Status:
Completed
Trial end date:
2019-05-01
Target enrollment:
Participant gender:
Summary
Anorexia nervosa is an eating disorder that can cause thinning of the bones (a decrease in
bone density). A significant decrease in bone density is called osteopenia or osteoporosis.
Sometimes the loss of bone density can be severe enough to cause breaks and fractures of the
bones. It is not known what causes the bones to thin in anorexia nervosa. Women who have this
condition often have thin or weak bones that are more likely to break. They also have very
low levels of a chemical called IGF-1 in their body. This chemical is very important for
increasing bone growth in puberty and for maintaining healthy adult bones. The investigators
would like to find out if giving rhIGF-1 followed by risedronate or risedronate alone can
lead to an increase in bone formation, bone density, and bone strength in women with anorexia
nervosa.