ICCRT vs. CRT for Locally Advanced Nasopharyngeal Carcinoma

• Status: Recruiting
• Trial end date: 2027-08-31
• Target enrollment: 0
• Participant gender: All

Summary

This trial is a multi-center phase III clinical trial. The purpose of this trial is to explore whether concurrent chemoradiotherapy is not inferior to induction chemotherapy combined with concurrent chemoradiotherapy in patients with locally advanced nasopharyngeal carcinoma.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: First Affiliated Hospital, Sun Yat-Sen University

Criteria

Inclusion Criteria:

1. Age 18-65 years old;

2. Pathologically confirmed non-keratinizing nasopharyngeal carcinoma;

3. Stage T3-4N0-1 (according to the UICC/AJCC 8th);

4. No distant metastasis;

5. Have not received anti-cancer treatment in the past;

6. ECOG (Eastern Cooperative Oncology Group of the United States): 0-1;

7. Adequate hematologic, hepatic and renal function.

Exclusion Criteria:

1. The purpose of treatment is palliative;

2. Diagnosed with other malignant tumors at the same time;

3. Malignant tumor history;

4. Pregnancy or breastfeeding, or expect to become pregnant during the clinical trial period;

5. Combined serious illness.