Hypothyroidism, Metabolism and Quality of Life - Focus on QOL, REE, Cognitive Function and Body Composition
Status:
Completed
Trial end date:
2018-05-20
Target enrollment:
Participant gender:
Summary
This project has the following primary aims:
The main objective is to delineate the association between changes in Resting energy
expenditure (REE) and QOL in hypothyroid patients before and after one year of L-T4
treatment. To achieve this, the investigators plan to compare newly diagnosed hypothyroid
patients soon after diagnosis before L-T4 therapy has been initiated after 6 months and after
1 year of treatment.
Primary endpoint is changes in REE compared to changes in QOL Secondary endpoint is changes
in cognitive function and changes in body composition before and after one year of treatment
and furthermore changes in insulin resistance following changes in body composition and free
fatty acids (FFA).