Hypoglycemia Associated Autonomic Failure in Type 1 DM
Status:
Completed
Trial end date:
2008-10-01
Target enrollment:
Participant gender:
Summary
It is unclear what effect selective serotonin reuptake inhibitors (SSRIs) have on
hypoglycemia. Thus, the American Hospital Formulary Service recommends careful monitoring of
blood glucose levels in all patients with diabetes initiating or discontinuing SSRIs (Katz et
al., 1996). Because of the increased prevalence of depression in those with diabetes, it is
critical to discover what affect the antidepressant therapy may have on counterregulatory
responses to hypoglycemia. This study hypothesizes that chronic administration of SSRIs may
result in a blunted counterregulatory response to hypoglycemia, thereby leaving individuals
more susceptible to hypoglycemia.
Phase:
N/A
Details
Lead Sponsor:
Vanderbilt University Vanderbilt University Medical Center
Collaborator:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)