Hypertonic Saline for Outpatient Bronchiolitis

• Status: Unknown status
• Trial end date: 2008-10-01
• Target enrollment: 0
• Participant gender: All

Summary

We will study if small children who become ill with respiratory distress during the RSV epidemic are better relieved with salbutamol nebulizations diluted in hypertonic (3%), instead of normal (0.9%) saline.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Diego Portales
• Collaborator: Clínica Vespucio, Santiago, Chile
• Treatments: Albuterol

Criteria

Inclusion Criteria:

1. Age 1 to 24 months

2. Mild to moderate respiratory distress (Tal score below 9)

3. Up to 5 days of respiratory symptoms, including today

4. Expiratory wheezing heard on chest auscultation

5. Indication of salbutamol nebulization treatment by attending physician

Exclusion Criteria:

1. Two prior episodes of wheezing

2. Premature birth (below 38 weeks), if below 6 months of age

3. Lobar pneumonia

4. Body temperature above 38 degree Celsius

5. Use of salbutamol during the previous 6 hours

6. Pulse oxymetry reading below 90%

7. Congenital heart disease

8. Chronic pulmonary disease: Asthma, cystic fibrosis, bronchopulmonary dysplasia

9. Other chronic or genetic condition or disease