Hypertonic Saline With Dextran for Treating Hypovolemic Shock and Severe Brain Injury

• Status: Completed
• Trial end date: 2007-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to evaluate the clinical outcome of patients following blunt traumatic injury with hypovolemic shock, who receive either lactated ringer's solution or hypertonic saline with dextran (HSD) resuscitation; also, to focus specifically on neurologic outcome in patients with brain injury and on the effect of HSD resuscitation on inflammatory cell responsiveness.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Washington
• Collaborator: National Heart, Lung, and Blood Institute (NHLBI)
• Treatments: Dextrans; Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• Recent blunt trauma

• Of adult size if age is unknown

• Pre-hospital systolic bloood pressure 90 mm Hg or less

• Altered mental status

• Transported directly to Harborview Medical Center from the injury event

Exclusion Criteria:

• Ongoing CPR

• Transferred from outside hospitals

• Pregnant or suspected pregnancy

• Presence of injuries from penetrating trauma

• Receiving more than 2000 cc of crystaloid prior to study fluid administration