Patients with decompensated heart failure have high rates of mortality and morbidity despite
recent improvements in diagnosis and treatment. Some aspects of their presentation such as
renal failure, hyponatremia and congestive phenomena have received special attention, as they
are associated with worse prognosis. The infusion of hypertonic saline solution has been
tested in different conditions of cardiovascular collapse. Current evidence indicates that
the infusion of hypertonic solution in heart failure patients can provide clinical and
haemodynamic improvement. The investigators are testing the hypothesis that the infusion of
hypertonic solution in association with diuretics may prevent the occurrence of renal
dysfunction in patients with decompensated heart failure.
Phase:
Phase 2
Details
Lead Sponsor:
University of Sao Paulo
Collaborator:
Fundação de Amparo à Pesquisa do Estado de São Paulo