Hypertonic Resuscitation Following Traumatic Injury
Status:
Terminated
Trial end date:
2009-08-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine if hypertonic saline with and without dextran can
improve overall survival in victims of trauma with shock.
Injury and lost blood from trauma can cause your body to be in shock (low blood pressure
related to blood loss). This decreased blood flow can lead to organ damage. In order to
restore the blood pressure and blood flow, the medics give fluids into the patients' veins as
soon as possible. This is called "resuscitation." The resuscitation fluid most commonly used
is "isotonic" or one that is the same concentration as the blood. The investigators are
trying to determine if infusing a "hypertonic" fluid (or one more concentrated than the
blood) can increase the blood pressure and restore blood flow more efficiently. The
hypertonic fluids the investigators are using are called hypertonic saline with dextran (HSD)
and hypertonic saline (no dextran). Hypertonic saline is a salt solution that is slightly
more concentrated than your blood. Dextran is a sugar solution.
Phase:
Phase 3
Details
Lead Sponsor:
University of Washington
Collaborators:
Defence Research and Development Canada National Heart, Lung, and Blood Institute (NHLBI) National Institute of Neurological Disorders and Stroke (NINDS) The Institute of Circulatory and Respiratory Health (ICRH)