Hyperthermic Intra-Peritoneal Chemotherapy (HIPEC) in Relapse Ovarian Cancer Treatment

• Status: Active, not recruiting
• Trial end date: 2024-09-01
• Target enrollment: 0
• Participant gender: Female

Summary

CHIPOR hypothesis is that the adjunction of platinum HIPEC in first relapsed epithelial ovarian cancer is able to improve the median Overall Survival (OS) by 12 months. In that hypothesis, with alpha risk of 5%, a power beta of 80%, during a 3 years period of inclusion and a 3 years follow-up, the number of patients to include is 404. Taking into account a 10% failure, an overall number of 444 patients is required.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: UNICANCER

Criteria

Inclusion Criteria:

• Patient age ≥ 18 years

• Performance Status WHO < 2

• Initially treated for Epithelial Ovarian Carcinoma

• Patient with only peritoneal relapse occurred at least 6 month from the initial treatment, resectable without distant metastasis (with the exception of communicating pleura effusion, sensitive to platine-based second line chemotherapy and resectable lymph-nodes in the groin or retro peritoneal)

• Platinum based second-line chemotherapy before surgery with either carboplatine-paclitaxel, or carboplatine-caelyx

• Complete cytoreductive surgery

• The surgery has to be planned 5 to 8 weeks from the last 2nd of chemotherapy

• No hepatic failure, bilirubin ≤ 1,5 time the Normal limit, ASAT and ALAT ≤ 3 time the Upper Normal Limit

• No Renal insufficiency (serum creatinine < 1,5 time the normal limit, creatinine clearance > 80 mL/min). calculated with MDRD method

• Hematology function: PNN ≥ 1,5x10⁹/L, platelets ≥ 100x10⁹/L

• No contraindication to general anaesthesia for heavy surgery

• Patients having read, signed and dated Informed consent before any study procedure

• Childbearing patients have to take appropriate contraceptive methods during the treatment and until 6 months after the treatment

Exclusion Criteria:

• Patient age <18 years

• Previous cancer in the last 5 years (except cutaneous baso-cellular epithelioma or uterine peripheral epithelioma)

• Hypersensitivity to Platinum compound

• Distant metastasis

• Use of anti-angiogenic treatment

• Patient with other concurrent severe life threatening disease

• The need to perform more than two segmental digestive resections during the CRS +/- HIPEC surgery

• Any progressive disease during the IV systemic second-line chemotherapy (platine-based)

• Incomplete cytoreductive surgery with macroscopical residual disease (Sugarbaker > CC1)

• Early relapse: less than 6 mois after the end of the first treatment

• Ovarian tumor other than Epithelioma Ovarian Cancer

• Uncontrolled infection

• Patients with any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule

• Clinically significant cardiovascular disease contraindicating the hyper hydratation, which is necessary for HIPEC

• Patient already treated with HIPEC for the ovarian cancer

• Individual deprived of liberty or placed under the authority of a tutor