Overview

Hyperthermia and Olaparib in Treating Breast Cancer Patients With Chest Wall Recurrences

Status:
Active, not recruiting
Trial end date:
2023-10-01
Target enrollment:
Participant gender:
Summary
This phase I trial studies the side effects and best dose of olaparib when given with hyperthermia in treating patients with breast cancer that has come back in the chest wall. Olaparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Hyperthermia treatment may kill or damage tumor cells by heating them to several degrees above normal body temperature. Giving olaparib and hyperthermia treatment may work better in treating patients with breast cancer that has come back in the chest well compared to standard of care.
Phase:
Phase 1
Details
Lead Sponsor:
Thomas Jefferson University
Collaborator:
AstraZeneca
Treatments:
Olaparib
Poly(ADP-ribose) Polymerase Inhibitors