Hypertensive Ambulatory Trial to Compare the Efficacy of HCTZ and Lisinopril

• Status: Completed
• Trial end date: 2014-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this trial is to evaluate if an objective clinical decision of anti-hypertensive therapy can be made using an N-of-1 (single patient) trial design.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Scripps Translational Science Institute
• Treatments: Angiotensin-Converting Enzyme Inhibitors; Hydrochlorothiazide; Lisinopril

Criteria

Inclusion Criteria:

• Diagnosis of Grade 1 Hypertension

• Treatment naïve

• GFR > 60 within previous 3 months

• Urinary microalbumin level normal during previous 3 months

Exclusion Criteria:

• Pregnancy (Fetal morbidity and mortality may occur with the use of ACE inhibitors.)

• Uncontrolled Hyperthyroidism

• Sleep Apnea

• Primary Aldosteronism

• Renovascular Disease

• Cushing's Syndrome or steroid therapy

• No evidence of end organ damage

• EKG with evidence of LVH within previous 3 months

• Collagen Vascular Disease

• Current Smoker