Hypertension in Young Adults Trial

• Status: Recruiting
• Trial end date: 2027-05-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a pilot randomized controlled trial which will test the effect of 3 different anti-hypertensive agents and 3 different strategies of engaging young adults in home blood pressure monitoring on blood pressure control, with secondary outcomes focused on quality of life and adverse events.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of California, San Francisco
• Treatments: Amlodipine; Antihypertensive Agents; Chlorthalidone; Losartan

Criteria

Inclusion Criteria:

• 18-35 years of age

• Diagnosis of hypertension or receiving anti-hypertensive therapy OR Has clinical BP readings >130/80 mmHg that would meet the definition of hypertension and have home BP readings >=125/80 mmHg

Exclusion Criteria:

• are or are planning to become pregnant, due to inability to take multiple classes of anti- hypertensive agents

• are marginally housed, due to concerns regarding routine follow-up

• are actively participating in a different interventional trial that may affect blood pressure

• are unwilling to consent to participate

• institutionalized individuals or prisoners

• are actively abusing illicit drugs or alcohol

• have a history of poor or doubtful compliance (e.g., frequently missed appointments)

• are already taking ≥3 anti-hypertensive medications (any classes, including diuretics)

• have cognitive impairment prohibiting participation in the study

• History of allergy to any of the randomized medications

• Serum potassium >5.5 meq/L at the screening visit

• BP > 160/100 mmHg in clinic (stage II hypertension), regardless of whether patient is on therapy

• eGFR < 60 mL/min/1.73 m2