Hypertension In Postpartum Preeclampsia Study

• Status: Completed
• Trial end date: 2019-10-01
• Target enrollment: 0
• Participant gender: Female

Summary

This study aims to evaluate whether NSAIDs (Non-steroidal antiinflammatory drugs) administered during the postpartum period influence blood pressure in women with hypertensive disorders of pregnancy. The study design is a prospective double blinded randomized control trial with participants randomized to receive postpartum analgesic regimens with and without NSAIDs.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: MemorialCare Health System
• Treatments: Acetaminophen; Ibuprofen

Criteria

Inclusion Criteria:

• Delivery occurred at equal to or greater than 24 0/7 weeks gestational age

• Patient receiving care with the Women's Perinatal Group (Maternal Fetal Medicine practice) or Obstetric Clinic resident services

• Diagnosis of a hypertensive disorder of pregnancy (HDP), including the following:

• Gestational hypertension

• Preeclampsia without severe features

• Preeclampsia with severe features

• Hemolysis, Elevated Liver Enzymes, Low Platelet (HELLP) Syndrome

• Eclampsia

Exclusion Criteria:

• Diagnosis of chronic hypertension or documentation of elevated blood pressures before 20 weeks gestational age.

• Severe hypertension: Patients with at least one severe blood pressure measurement (systolic >160mmHg or diastolic >105mmHg) prior to randomization

• Renal dysfunction (Serum creatinine measurement >1.3mg/dL during the current pregnancy)

• Low platelet count (recorded measurement <50,000 during hospital admission)

• Significant liver dysfunction (AST or ALT >500)

• Known sensitivities to ibuprofen or acetaminophen

• Use of therapeutic doses of anticoagulation (low dose anticoagulation used for routine prophylaxis of venous thromboembolism is acceptable)

• Postpartum hemorrhage requiring transfusion