The aim of this trial is to study the effects of antihypertensive therapy based on home
systolic blood pressure (BP) with different target levels using two classes of drugs.
The HOSP study is a multicenter, prospective, randomized, open, blinded endpoint study. The
study subjects are 40-79 years old hypertensive patients. After a 4 weeks of baseline period,
subjects are randomly assigned to (1) modest control group (morning home BP <140 mmHg) or (2)
strict control group (morning home BP <130 mmHg), and to (a) amlodipine group or (b) losartan
group. Additional antihypertensive drugs can be used if home BP is not controlled. Home BP is
measured in the early morning and late evening. The participants will be followed up for 5
years.