Hypertension Control Based on Home Blood Pressure

• Status: Unknown status
• Trial end date: 2012-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this trial is to study the effects of antihypertensive therapy based on home systolic blood pressure (BP) with different target levels using two classes of drugs.

The HOSP study is a multicenter, prospective, randomized, open, blinded endpoint study. The study subjects are 40-79 years old hypertensive patients. After a 4 weeks of baseline period, subjects are randomly assigned to (1) modest control group (morning home BP <140 mmHg) or (2) strict control group (morning home BP <130 mmHg), and to (a) amlodipine group or (b) losartan group. Additional antihypertensive drugs can be used if home BP is not controlled. Home BP is measured in the early morning and late evening. The participants will be followed up for 5 years.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ministry of Health, Labour and Welfare, Japan
• Collaborator: Japan Cardiovascular Research Foundation
• Treatments: Amlodipine; Angiotensin Receptor Antagonists; Antihypertensive Agents; Losartan

Criteria

Inclusion Criteria:

• Clinical diagnosis of hypertension

Exclusion Criteria:

• Severe hypertension (treated with 3 or more antihypertensive drugs)

• Unable to change antihypertensive drugs to a calcium antagonist or an angiotensin antagonist

• Serious medical conditions

• Women who may become to be pregnant