Hyperproteic Diet Plus Lactobacillus Reuteri and Nitazoxanide in Minimal Hepatic Encephalopathy

• Status: Completed
• Trial end date: 2014-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Hepatic encephalopathy is a serious complication of cirrhosis which relays under the burden of diseases with therapeutical difficulties for its given morbidity and mortality and the high recurrence it poses. Its treatment remains a challenge for most of the cases. Even more, minimal hepatic encephalopathy is an entity that has an additional morbidity for it being a subclinical entity. As so, the investigators propose an auxiliary treatment for the management of such patients with minimal hepatic encephalopathy, using a specific diet consisting on hyperproteic and fibre-rich foods along with two independent interventions, whether a probiotic, lactobacillus reuteri, or a drug, nitozoxanide, so to diminish the rate of progression to any clinical stage of hepatic encephalopathy and to revert minimal hepatic encephalopathy itself to none hepatic encephalopathy.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
• Treatments: Nitazoxanide

Criteria

Inclusion Criteria:

• Hepatic Cirrhosis

• Minimal hepatic Encephalopathy

Exclusion Criteria:

• Personal history of surgery in the last 4 weeks

• Use of neuropsychiatric drugs

• Neuropsychiatric disorders (Schizophrenia, bipolar disorder, major depression, dementia and Attention-deficit hyperactivity disorder)

• Thyroid disorders without replacement therapy

• Hepatic or renal transplant

• Alcoholism with active ingest of alcohol in the last 6 months

• Pregnancy

• Labour turn-overs

• Spontaneous bacterial Peritonitis

• Personal history of hepatocellular carcinoma

• Placement of transjugular intrahepatic portosystemic shunt

• Use of a probiotic in the last 6 months