Over the past 10 years, electronic cigarettes (e-cigarettes, EC) have been commercialized as
a "less harmful" alternative to traditional cigarettes.1,2 However, e-cigarettes are believed
to cause pulmonary epithelial, endothelial and vascular dysfunction, and to cause murine
phenotypes similar to those of human COPD. Recently, "spiked" vape juice has been linked to
severe lung damage. Unfortunately, the effects of e-cigarettes on the human lungs are still
poorly understood, especially in healthy young adults. Therefore, establishing the health
effects of e-cigarettes in humans is of paramount importance to guide medical and regulatory
decision making. Its widespread use and immense popularity among teenagers and young adults
have caused major concern given potentially significant addictive and detrimental long-term
health effects.