Hyperpolarized 129Xe MRI for Imaging Pulmonary Function
Status:
Recruiting
Trial end date:
2022-12-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to develop and evaluate the usefulness of MRI using 129Xe gas
for regional assessment of pulmonary function. Specifically, three forms of 129Xe MRI
contrast will be the investigators focus - 1) imaging of the 129Xe ventilation distribution,
2) imaging the alveolar microstructure via the 129Xe apparent diffusion coefficient (ADC),
and 3) imaging 129Xe that dissolves in the pulmonary blood and tissues upon inhalation. Such
imaging of 129Xe gas transfer is expected to be uniquely sensitive to pathologies affecting
gas exchange (fibrosis, emphysema, pulmonary hypertension) and provide new insights regarding
the normal resting heterogeneity of pulmonary gas exchange.