Overview

Hyperbaric Oxygen Therapy Compared With Standard Therapy in Treating Chronic Arm Lymphedema in Patients Who Have Undergone Radiation Therapy for Cancer

Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Hyperbaric oxygen therapy may be effective in repairing damaged tissue and reducing lymphedema caused by radiation therapy for cancer. PURPOSE: This randomized phase II trial is studying hyperbaric oxygen to see how well it works compared to standard therapy in treating chronic arm lymphedema in patients who have undergone radiation therapy for cancer.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Institute of Cancer Research, United Kingdom
Criteria
DISEASE CHARACTERISTICS:

- History of early breast cancer (T1-3, N0-1, M0)

- Prior breast surgery with or without axillary dissection

- Prior breast/chest wall radiotherapy with or without radiotherapy to the
supraclavicular fossa and/or axilla, completed at least 2 years ago

- Arm lymphedema

- At least 15% increase in arm volume

- No evidence of cancer recurrence

- Hormone receptor status:

- Not specified

PATIENT CHARACTERISTICS:

Age

- Over 18

Sex

- Female or male

Menopausal status

- Not specified

Performance status

- Not specified

Life expectancy

- Not specified

Hematopoietic

- Not specified

Hepatic

- Not specified

Renal

- Not specified

Pulmonary

- No chronic obstructive airway disease

- No bullous lung disease

- No acute or chronic pulmonary infection

- No uncontrolled asthma

- No untreated pneumothorax

Other

- Physically and psychologically fit for HBO therapy

- No claustrophobia

- No epilepsy

- No eustachian tube dysfunction

- No recurrent attacks of vertigo

- No contraindication to MRI (e.g., intracranial ferrous material)

PRIOR CONCURRENT THERAPY:

Biologic therapy

- Not specified

Chemotherapy

- Not specified

Endocrine therapy

- Not specified

Radiotherapy

- See Disease Characteristics

Surgery

- See Disease Characteristics

- No prior ear operations

Other

- No prior hyperbaric oxygen (HBO) therapy, except as treatment for decompression
illness