Hyperbaric Oxygen Therapy Attenuates Central Sensitization Induced by a Thermal Injury in Human Volunteers (HBO)
Status:
Completed
Trial end date:
2012-10-01
Target enrollment:
Participant gender:
Summary
The hypothesis of this investigation is to observe if HBO have an anti-inflammatory effect in
humans induced by tonic heat stimulation. It has been shown in animal studies with rats that
HBO could reduce the paw edema induced by carrageenan as an inflammatory agent. The authors
are not aware of similar studies in human subjects investigating this effect of HBO. Aim: To
investigate the anti-inflammatory effect of HBO by reducing the hyperalgesia induced by heat
stimulation in healthy subjects and promote future research and understanding of the
anti-inflammatory processes in humans. The primary endpoint is a reduced area of secondary
hyperalgesia after HBO.