Hyperandrogenemia and Altered Day-night LH Pulse Patterns
Status:
Recruiting
Trial end date:
2025-12-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to determine if, in mid- to late pubertal girls with
hyperandrogenism, androgen-receptor blockade (spironolactone) improves the ability of
progesterone to acutely reduce waking luteinizing hormone pulse frequency (primary endpoint).
Phase:
Early Phase 1
Details
Lead Sponsor:
University of Virginia
Collaborator:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)