Hyperalgesia, Persistent Pain, and Fentanyl Dosing in On-Pump Coronary Artery Bypass Grafting

• Status: Completed
• Trial end date: 2021-01-09
• Target enrollment: 0
• Participant gender: All

Summary

Randomized, double-blinded, three arm study in adult patients undergoing first time coronary artery bypass grafting (CABG) surgery with median sternotomy. The investigators will examine the effects of three fentanyl dosing schemes (high-dose bolus, low-dose bolus, continuous dose) on the area of hyperalgesia and allodynia at 24 and 48h as well as on persisting pain at 3, 6, and 12 months. Additionally, the investigators will measure fentanyl concentrations throughout anesthesia.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Ghent
• Collaborator: University Hospital, Basel, Switzerland
• Treatments: Fentanyl

Criteria

Inclusion Criteria:

• Consenting patients aged ≥18 years

• Undergoing first-time, elective, on-pump CABG surgery with median sternotomy and central cannulation.

Exclusion Criteria:

• Documentation of preexisting chronic pain as per electronic record

• Use of opioids in the last 30 days or history/documentation of opioid abuse as per electronic record

• BMI > 35kg/m2 or history of obstructive sleep apnea syndrome

• Patients with renal failure (clearance < 30 ml/min)

• Neuraxial anesthesia

• Pregnancy

• Planned wound infiltration with local anesthetics

• Known drug allergies or intolerance to fentanyl or other opioids

• Expected to be unable to understand pinprick/allodynia testing / follow-up questions