Hyper Polarized Xenon-129 MRI vs Xenon-133 Scintigraphy

• Status: Recruiting
• Trial end date: 2020-12-31
• Target enrollment: 0
• Participant gender: All

Summary

Hyper polarized Xenon-129 MRI will be directly compared to a radioactive Xe-133 scintigraphy to detect defects in lung ventilation from airflow limitation. This study is conducted as a pilot study with intention to conduct a larger clinical trial.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Virginia
• Treatments: Xenon

Criteria

Inclusion Criteria:

• Subjects must have a diagnosis of COPD

• at their clinical baseline on the day of imaging

• must be clinically stable in order to participate in the study.

• COPD subjects will be categorized according to the GOLD

• Current/Former SmokerSubjects

• must have a smoking history ≥ 10 pack years

Exclusion Criteria:

• Dx of asthma

• Continuous oxygen use at home

• Blood oxygen saturation of 92% less than as measured by pulse oximetry on the day of imaging

• FEV1 percent predicted less than 25%

• Pregnancy or lactation

• Claustrophobia, inner ear implants, aneurysm or other surgical clips, metal foreign bodies in eye, pacemaker or other contraindication to MR scanning

• Subjects with any implanted device that cannot be verified as MRI compliant will be excluded

• Chest circumference greater than that of the xenon MR and/or helium coil. The circumference of the coil is approximately 42 inches

• History of congenital cardiac disease, chronic renal failure, or cirrhosis

• Inability to understand simple instructions or to hold still for approximately 10 seconds

• History of respiratory infection within 2 weeks prior to the MR scan

• History of MI, stroke and/or poorly controlled hypertension.