Hydroxychloroquine to Prevent COVID-19 Disease Amongst Healthcare Workers

• Status: Withdrawn
• Trial end date: 2020-08-30
• Target enrollment: 0
• Participant gender: All

Summary

The objectives of PROVIDE are to:

1. Determine if prophylactic once weekly hydroxychloroquine reduces the incidence of conversion from SARS-2-CoVnasopharyngeal swab negative to positive

2. To determine if weekly prophylactic hydroxychloroquine reduced the severity of COVID-19 symptoms

3. To determine the safety of taking weekly prophylactic hydroxychloroquine

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: St. Joseph's Healthcare Hamilton
• Treatments: Hydroxychloroquine

Criteria

Inclusion Criteria:

• 18 years of age or older to participate.

• Healthcare workers with primary practice in intensive care unit, general internal medicine,

• COVID-19 testing centres, emergency rooms, and nursing homes.

• COVID_19 symptom free at the time of randomization and have a negative diagnostic swab.

Exclusion Criteria:

• Known COVID-19 positivity defined as: a laboratory confirmed case as defined by the local public health institutes

• Suspected COVID-19 positivity defined as possessing symptoms consistent with COVID-19 infections such as: headache, fever, nausea, vomiting, diarrhea, dyspnea, dry cough

• Healthcare workers with pre-existing retinopathy or serious visual problems

• Healthcare workers with known malignancies receiving active chemotherapy or immune modifying medications

• Healthcare workers with known autoimmune disorders

• Healthcare workers with known QT prolongation

• History of ventricular arrhythmias

• Participants at risk of malignant arrythmias ○ At risk defined as: A sudden loss of consciousness with injury; anyone in their immediate family, under the age of 45year, with sudden cardiac death; anyone family history of long QT syndrome

• Known sensitivity/allergy to hydroxychloroquine

• Healthcare workers that are currently pregnant

• Healthcare workers that are already taking chloroquine or hydroxychloroquine

• Healthcare workers on colchicine or any other anti-viral medication

• Healthcare workers taking a medication that may interact with hydroxychloroquine (see table below

• Inability to take oral medications

• Inability to provide written consent

• Known G6PD deficiency