Hydroxychloroquine for Prevention of Recurrent Miscarriage.
Status:
Recruiting
Trial end date:
2026-02-01
Target enrollment:
Participant gender:
Summary
Recurrent miscarriage (RM) defined by >=3 consecutive losses affects 1% of fertile couples.
Most women have recurrent early loss with a failure of development before 10 weeks'
gestation. Standard investigations fail to reveal any apparent cause in >50% of couples.
No study has demonstrated any benefit of any medication in women with Unexplained RM, in the
presence or absence of an inherited thrombophilia.
Moreover, the benefit of aspirin and/or heparin has not been proved in women with
Antiphospholipid (APL) antibody without other clinical manifestations of Antiphospholipid
Syndrome.
Hydroxychloroquine (HQ) is a molecule whose properties (anti-thrombotic, vascular-protective,
immunomodulatory, improved glucose tolerance, lipid-lowering, anti-infectious) could be
useful against mechanisms of Unexplained RM.
There is no data concerning the benefit of HQ in RM in the presence or absence of
antiphospholipid antibodies or any inherited thrombophilia.
Administration in (Systemic Lupus erythematosus (SLE) women and for Malaria prevention
provides extensive safety data during pregnancy.
Oral administration makes possible treatment since the preconception period. For all of that
and its low cost, hydroxychloroquine should be evaluated in RM whatever the woman
thrombophilic status.