Overview
Hydroxychloroquine and Unexplained Recurrent Miscarriage
Status:
Active, not recruiting
Active, not recruiting
Trial end date:
2022-03-01
2022-03-01
Target enrollment:
0
0
Participant gender:
Female
Female
Summary
Recurrent miscarriage affects women of childbearing age worldwide. Vascular endothelial dysfunction and immunological impairment are associated with both recurrent miscarriage and preeclampsia. To date, there is no effective or optimal therapeutic approach for these conditions. Hydroxychloroquine has endothelial protective action via ant diabetic, lipid lowering, antioxidant effects or direct endothelial protection. Hydroxychloroquine is an antimalarial and immunomodulatory agent. In pregnancy, hydroxychloroquine is prescribed for inflammatory conditions associated with adverse perinatal outcomes such as systemic lupus erythematosus, antiphospholipid syndrome and placental inflammatory lesions such as chronic histiocytic intervillositis, hydroxychloroquine has therapeutic potential to improve placental function in pregnancies associated with heightened inflammation.Phase:
N/AAccepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Assiut UniversityTreatments:
Aspirin
Folic Acid
Hydroxychloroquine
Criteria
Inclusion Criteria:- Women had at least 2 previous miscarriage before 20 weeks.
- Women trying to conceive.
- No anatomical or endocrine cause of recurrent pregnancy loss.
- Women who have given their informed consent.
- The negative antibody test for antiphospholipid syndrome
Exclusion Criteria:
- Women who are already pregnant.
- Known contraindication to treatment by Hydroxychloroquine (
- Patients already using Hydroxychloroquine
- Impossible to follow-up.