Hydroxychloroquine and Temsirolimus in Treating Patients With Metastatic Solid Tumors That Have Not Responded to Treatment
Status:
Completed
Trial end date:
2013-11-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as hydroxychloroquine, work in different ways to
stop the growth of tumor cells, either by killing the cells or by stopping them from
dividing. Temsirolimus may stop the growth of tumor cells by blocking some of the enzymes
needed for cell growth. Giving hydroxychloroquine together with temsirolimus may kill more
tumor cells.
PURPOSE: This phase I trial is studying the side effects and best dose of hydroxychloroquine
when given together with temsirolimus in treating patients with metastatic solid tumors that
have not responded to treatment.
Phase:
Phase 1
Details
Lead Sponsor:
Abramson Cancer Center of the University of Pennsylvania