Hydromorphone Versus Prochlorperazine + Diphenhydramine for Acute Migraine

• Status: Completed
• Trial end date: 2016-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Opioids are commonly used to treat migraine in North American Emergency Departments. We are comparing efficacy and adverse events of hydromorphone, an opioid, to that of prochlorperazine, a dopamine antagonist with known efficacy in migraine. Prochlorperazine will be combined with diphenhydramine to prevent adverse events.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Montefiore Medical Center
• Treatments: Diphenhydramine; Hydromorphone; Prochlorperazine; Promethazine

Criteria

Inclusion Criteria:

• Migraine headache (International Classification of Headache Disorders 3B criteria)

Exclusion Criteria:

• Brain imaging ordered

• Fever

• Objective neurological findings

• Pregnancy/ breast feeding

• Allergy/ contraindication to investigational medication

• History of addiction to opioids, use of methadone, any use of opioids previous 30 days