Hydrocortisone Per-treatment Decrease Side Effects of Protamine Sulfate

• Status: Completed
• Trial end date: 2020-06-01
• Target enrollment: 0
• Participant gender: All

Summary

This study aims to compare the hemodynamic parameters within and between patients who received Protamine Sulfate (PS) with Hydrocortisone (HC) vs. Protamine Sulfate alone during cardiac surgeries.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Jordan
• Treatments: Hydrocortisone

Criteria

Inclusion Criteria:

• Patients who had cardiac surgery using cardiopulmonary bypass

• Normal preoperative hemoglobin level

• Normal preoperative platelet count

• No known defect of the coagulation system

• Patients with unimpaired renal function (creatinine clearance < 30 ml/kg/min)

Exclusion Criteria:

• Patients younger than 18 years

• Patients with known defect of the coagulation system

• Renal impairment

• Previous vasectomy

• Allergy to fish

• Unable to give consent form