Hydrocortisone 50 mg Every 6 Hours Compared to Hydrocortisone 300 mg Per Day in Treatment of Septic Shock.
Status:
Completed
Trial end date:
2014-09-01
Target enrollment:
Participant gender:
Summary
We performed a multicenter, prospective, randomized, double-blind, pilot study in four adult
medical intensive care units. Patients presenting septic shock were rapidly administered one
of two regimens of hydrocortisone, either a 50-mg intravenous bolus every six hours during
seven days (200-mg group) or a 100-mg initial bolus followed by a continuous infusion of 300
mg daily for five days (300-mg group). Hydrocortisone was stopped abruptly at the end of
treatment.