Hydrochloric Acid Lock Therapy in Children With Cancer
Status:
Not yet recruiting
Trial end date:
2024-07-01
Target enrollment:
Participant gender:
Summary
Aim: This study will test whether treatment of central line associated bloodstream infection
(CLABSI) with hydrochloric acid lock therapy (HALT) can significantly reduce the risk of
treatment failure (comprising failure to clear initial infection, relapse or reinfection) in
children and adolescents treated for cancer.
Study design: A multicenter, double-blind, randomized controlled trial.The assignment is
parallel, with cross-over in case of reinclusion of the patient.
Patients and randomisation: A target population of 100 children and adolescents treated for
cancer will be enrolled within 48 hours after detection of a positive blood culture/CLABSI.
They will be randomized as followed:
- Intervention group: HALT.
- Control group: Normal saline (placebo).
In addition to the study intervention, participants in both arms will receive standard
systemic antibiotic therapy according to the preference of the ward clinician.
Phase:
N/A
Details
Lead Sponsor:
Rigshospitalet, Denmark
Collaborators:
Aarhus University Hospital Skejby Odense University Hospital