Overview

Hyaluronidase in Intra-articular Steroid Injection Treating the Adhesive Capsulitis for Shoulder

Status:
Completed
Trial end date:
2019-07-16
Target enrollment:
0
Participant gender:
All
Summary
Adhesive capsulitis (AC) is painful and disabling condition that is associated with a gradual loss of shoulder motion. Intra-articular steroid injection is a common treatment in the initial painful stage of AC, and its use in combination with hyaluronidase may offer increased therapeutic efficacy owing to synergistic effects. We determined the therapeutic efficiency of the co-administration of hyaluronidase in early AC by evaluating symptomatic, anthropometric, and imaging changes.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Veterans Health Service Medical Center, Seoul, Korea
Treatments:
Triamcinolone
Triamcinolone Acetonide
Triamcinolone diacetate
Triamcinolone hexacetonide
Criteria
Inclusion Criteria:

- Normal findings on simple x-rays of the shoulder but limitations in passive range of
motion on physical examination

- Increased intra-sheath fluid (ISF) sufficient to encircle the long head of the biceps
tendon within the upper portion of the bicipital groove of the humerus.

Exclusion Criteria:

- Ultrasonographic diagnosis of other concomitant fundamental abnormalities causing
shoulder pain such as rotator cuff tear, bicipital tendon rupture, calcific
tendinopathy, and subacromial-subdeltoid bursitis

- A history of shoulder injury

- A history of more than 1 year of conservative treatment for chronic shoulder pain

- Corticosteroid or hyaluronidase injections within the prior 6 months

- Hemiplegic shoulder

- Self-reported history consistent with scapula fracture or disarticulation

- Ipsilaterally cervical herniated intervertebral disc or brachial plexus injury

- Diabetes mellitus refractory to insulin therapy or glycated hemoglobin greater than
6.5

- Refusal to participate in this study