Background: Chronic periodontitis is one of the most common causes of tooth loss and is
rather common in the population. Treating chronic periodontitis remains a challenge for
dental practitioners. The purpose of this study was to assess the clinical effects of
sub-gingival application of 0.2% hyaluronic acid gel after root planing in the treatment of
chronic periodontitis.
Materials and Methods: In this split mouth study, 733 periodontal pockets of 28 patients with
moderate to severe chronic periodontitis were chosen for investigation. They were divided
into 2 groups: control group and experimental group. The experimental group received
sub-gingival administration of 1 ml of 0.2% hyaluronic acid gel into each pocket immediately
after root planing and then after 1 week, 2 weeks and 3 weeks. Clinical parameters were
assessed at baseline and 6 weeks after root planing. Subgingival plaque was assessed at
baseline and 6 weeks after root planing. Quantitative real-time PCR for Porphyromonas
gingivalis (Pg), Treponema denticola (Td), Fusobacterium nucleatum (Fn) Tannerella forsythia
(Tf) were performed at the same time.
Phase:
Phase 4
Details
Lead Sponsor:
Ho Chi Minh City University of Medicine and Pharmacy University of Medicine and Pharmacy at Ho Chi Minh City