Hyaluronan Versus NaCl 20 Ml Versus Placebo in Knee Osteoarthritis
Status:
Unknown status
Trial end date:
2001-11-01
Target enrollment:
Participant gender:
Summary
251 consecutive patients with knee arthrosis were randomized to one of three interventions:
Four weekly injections of 2 ml isotonic saline (placebo), 2 ml sodium hyaluronate
(hyaluronan) or 20 ml isotonic saline (excessive saline).
They all suffered from clinically and radiologically verified arthrosis of the knee with
daily pain that did not respond to treatment with analgetics.
Results were evaluated at weeks 1,2,3,4,8,12,16 and 26. Biochemical markers for bone and
cartilage degradation were measured in urine/blood.