Human Urinary Kallidinogenase Improve Short Term Motor Functional Outcome of Acute Ischemia Stroke Patients
Status:
Completed
Trial end date:
2019-08-25
Target enrollment:
Participant gender:
Summary
Acute cerebral infarction is a common type of ischemic stroke, causing brain dysfunction in
patients with high morbidity and disability. With the changes in people's diet, lifestyle
patterns and population aging, the incidence of acute cerebral infarction has increased year
by year, which has become an important cause of disability and death in middle-aged and
elderly patients. The human urinary kallidinogenase (HUK) was used in China in the management
of acute ischemic stroke (AIS) in recent years. However, the mechanism of HUK on AIS has not
been systematically investigated. This study aimed to assess the effect of HUK on motor
functional outcome and relative corticospinal tract recovery in the patients with AIS.
Diffusion tensor imaging(DTI) and diffusion tensor tractography(DTT) have all been used to
observe features of cerebral white matter fibrous structures. In addition, diffusion tensor
tractography which is used to trace fiber bundle and evaluate white matter fiber bundle
integrity and direction is the only non-invasive imaging method to display the corticospinal
tract in vivo.